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KMID : 0869220130170010020
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Journal of Korean Geriatric Psychiatry
2013 Volume.17 No. 1 p.20 ~ p.25
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Association between Cognitive Subdomains and Extrapyramidal Signs in Alzheimer Disease : A Clinical Research Center for Dementia of South Korea (CREDOS) Study
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Choi Jun-Bae
Myung Woo-Jae
Song Ji-Hye
Kim Sang-Ha
Yoon Hye-Yeon
Kang Hyo-Shin
Na Duk-Lyul
Kim Seong-Yoon
Lee Jae-Hong
Han Seol-Heui
Choi Seong-Hye
Kim Sang-Yun
Kim Doh-Kwan
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Abstract
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Objectives：We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD).
Methods：We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR- SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination.
Results： The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function.
Conclusion： The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.
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KEYWORD
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Alzheimer disease, Extrapyramidal signs, Cognitive symptoms
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